Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 7/20 | 0.34 |
| ▸ | DRD3 | P35462 | 7/20 | 0.34 |
| ▸ | DRD5 | P21918 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 7/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.34 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246923 | 0.81 | ADRA2B (0.40) | SCN9AHTR2AADRA2BADRA2CADRA2A | |
| SCHEMBL7248746 | 0.80 | GSK3A (0.51) | ADRA2BADRA2CADRA2ADRD2DRD3 | |
| SCHEMBL7241777 | 0.78 | SMN1; SMN2 (0.49) | HTR2ADRD2DRD3HTR1AHRH1 | |
| SCHEMBL7241537 | 0.77 | ALDH1A1 (0.52) | DRD3HTR7HTR1AHRH1SLC6A4 | |
| SCHEMBL7242765 | 0.77 | GSK3A (0.49) | ADRA2BADRA2CADRA2ADRD2DRD3 | |
| SCHEMBL7479946 | 0.76 | SCN9A (0.40) | SCN9AHTR2AADRA2BADRA2CADRA2A | |
| SCHEMBL7247950 | 0.76 | ADRA2A (0.44) | ADRA2BADRA2CADRA2ADRD2DRD3 | |
| SCHEMBL7241382 | 0.76 | ADRA2A (0.40) | SCN9AADRA2BADRA2CADRA2ADRD2 | |
| SCHEMBL7248585 | 0.75 | ACHE (0.40) | SCN9ADRD2DRD3HTR7CHRM2 | |
| SCHEMBL11883909 | 0.75 | CYP1A2 (0.41) | ADRA2BADRA2CADRA2AADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951466-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-10-27 | — | — | EP | claimed |
| WO-1998028268-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 1998-07-02 | — | — | WO | claimed |