Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480254 | 0.92 | GPR119 (0.44) | GPR119MAP4K4MEN1KMT2A | |
| SCHEMBL23360552 | 0.80 | GPR119 (0.49) | GPR119MAP4K4MEN1KMT2A | |
| SCHEMBL7483469 | 0.78 | ALDH1A1 (0.58) | GPR119MEN1KMT2AALDH1A1 | |
| SCHEMBL23360515 | 0.78 | GPR119 (0.48) | GPR119MEN1KMT2A | |
| SCHEMBL29862993 | 0.78 | GPR119 (0.48) | GPR119MEN1KMT2A | |
| SCHEMBL22608999 | 0.77 | PDE4B (0.57) | MEN1KMT2AHSD11B1ALDH1A1HPGD | |
| SCHEMBL2128743 | 0.77 | NPC1 (0.64) | MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL27391167 | 0.77 | MEN1 (0.53) | GPR119MEN1KMT2A | |
| SCHEMBL20765762 | 0.76 | L3MBTL1 (0.62) | MEN1KMT2AHSD11B1ALDH1A1HPGD | |
| SCHEMBL30826597 | 0.76 | MEN1 (0.46) | GPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |