Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479244 | 0.82 | BRD4 (0.52) | BRD4OPRM1OPRD1OGFRL1ACSS2 | |
| SCHEMBL29394473 | 0.71 | LCK (0.47) | NPC1RAB9ASMN1; SMN2MEN1GAA | |
| SCHEMBL7480580 | 0.71 | CSNK1A1 (0.39) | NPC1RAB9ATP53SMN1; SMN2GAA | |
| SCHEMBL533505 | 0.69 | RAB9A (0.62) | NPC1RAB9ATP53SMN1; SMN2MEN1 | |
| SCHEMBL31151002 | 0.69 | RAB9A (0.62) | NPC1RAB9ATP53SMN1; SMN2MEN1 | |
| SCHEMBL7473909 | 0.69 | CTSD (0.47) | NPC1RAB9ATP53SMN1; SMN2MEN1 | |
| SCHEMBL23582507 | 0.68 | SCN9A (0.52) | SCN9A | |
| SCHEMBL7486557 | 0.67 | SMN1; SMN2 (0.43) | BRD4NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL1721390 | 0.67 | SCN9A (0.54) | SMN1; SMN2ALDH1A1SCN9A | |
| SCHEMBL7474969 | 0.67 | DRD2 (0.54) | NPC1RAB9ATP53SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883622-B1 | PROTON PUMP INHIBITOR | APOTEX INC (CA) | 2002-05-15 | — | — | EP | disclosed |
| US-6114537-A | 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS | APOTEX INC. (CA) | 2000-09-05 | — | — | US | disclosed |
| US-6093738-A | IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT | KARIMIAN KHASHAYAR (CA) | 2000-07-25 | — | — | US | disclosed |