SCHEMBL7480280

SCHEMBL7480280

Nc1cc(Br)cc2nc(-c3cccs3)nn12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 5/20 0.59
KDM4E B2RXH2 6/20 0.40
ALDH1A1 P00352 5/20 0.40
MAPT P10636 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ADORA3 P0DMS8 4/20 0.39
ADORA1 P30542 3/20 0.39
RXFP1 Q9HBX9 2/20 0.39
PPARG P37231 1/20 0.39
RAB9A P51151 1/20 0.39
NCOA2 Q15596 1/20 0.39
NCOA1 Q15788 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NCOA3 Q9Y6Q9 1/20 0.39
POLB P06746 1/20 0.39
TSHR P16473 1/20 0.39
L3MBTL1 Q9Y468 3/20 0.39
CSNK2A1 P68400 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7429024 0.81 ADORA2A (0.39) ADORA2AKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7708740 0.81 ADORA2A (0.57) ADORA2AKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7153750 0.80 ADORA2A (0.71) ADORA2AKDM4EALDH1A1ADORA3ADORA1
SCHEMBL7432234 0.80 ADORA2A (0.56) ADORA2AKDM4EALDH1A1SMN1; SMN2MEN1
SCHEMBL7150367 0.80 ADORA2A (0.54) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7709150 0.78 ADORA2A (0.54) ADORA2AKDM4EALDH1A1SMN1; SMN2MEN1
SCHEMBL7705947 0.78 ADORA2A (0.54) ADORA2AKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7481231 0.78 ALDH1A1 (0.42) ADORA2AKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7434291 0.77 ALDH1A1 (0.57) ADORA2AKDM4EALDH1A1MAPTSMN1; SMN2
SCHEMBL7708573 0.76 ADORA2A (0.52) ADORA2AKDM4EALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214322-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-19 EP disclosed
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US disclosed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO disclosed