SCHEMBL7429024

SCHEMBL7429024

Nc1cc(Br)cc2nc(-c3cc(Br)cs3)nn12

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 11/20 0.39
TDP2 O95551 2/20 0.39
KDM4E B2RXH2 4/20 0.37
ALDH1A1 P00352 4/20 0.37
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
LMNA P02545 2/20 0.36
HPGD P15428 2/20 0.36
TP53 P04637 1/20 0.31
CYP2C19 P33261 1/20 0.31
NPC1 O15118 1/20 0.31
NFKB1 P19838 1/20 0.31
HTT P42858 1/20 0.31
RAB9A P51151 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7433615 0.85 KDM4E (0.39) ADORA2ATDP2KDM4EALDH1A1MAPT
SCHEMBL7480280 0.81 ADORA2A (0.59) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7481231 0.78 ALDH1A1 (0.42) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7711665 0.77 ALDH1A1 (0.39) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7428728 0.76 ALDH1A1 (0.43) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7428889 0.75 ADORA2A (0.44) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7434291 0.74 ALDH1A1 (0.57) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7427221 0.73 KDM4E (0.40) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7427300 0.72 ADORA2A (0.40) ADORA2AKDM4EALDH1A1MAPTMEN1
SCHEMBL7490670 0.71 ADORA2A (0.62) ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214322-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-19 EP disclosed
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US disclosed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO disclosed