Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | DNM2 | P50570 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480441 | 0.99 | NR4A2 (0.44) | NR4A2HCAR3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL2549528 | 0.82 | LMNA (0.52) | HCAR3MAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL6098426 | 0.80 | BRD4 (0.47) | TDP1 | |
| SCHEMBL5827758 | 0.78 | MAPT (0.41) | MAPTL3MBTL1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL3340185 | 0.78 | MAPT (0.38) | HCAR3MAPTL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL7480436 | 0.78 | HCAR3 (0.34) | NR4A2HCAR3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL6245357 | 0.77 | KMT2A (0.48) | HCAR3MAPTL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL413683 | 0.77 | MAPT (0.50) | MAPTL3MBTL1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL7479132 | 0.76 | CRHR1 (0.36) | HCAR3MAPTL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL31260423 | 0.76 | LMNA (0.34) | MAPTL3MBTL1ALDH1A1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448261-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS; TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC AND NEUROLOGICAL DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-10 | — | — | US | disclosed |
| EP-0935601-A4 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARM CO (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6107300-A | CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0935601-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | Du Pont Pharmaceuticals Company (US) | 1999-08-18 | — | — | EP | disclosed |
| WO-1997035539-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |