Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843301 | 0.90 | HCAR3 (0.41) | HCAR3CRHR1MAPTPOLBTDP1 | |
| SCHEMBL7479132 | 0.88 | CRHR1 (0.36) | HCAR3CRHR1MAPTPOLBTDP1 | |
| SCHEMBL5843957 | 0.85 | MAPT (0.46) | HCAR3CRHR1MAPTPOLBTDP1 | |
| SCHEMBL5845050 | 0.84 | CRHR1 (0.37) | HCAR3CRHR1MAPTTDP1L3MBTL1 | |
| SCHEMBL7478036 | 0.79 | CRHR1 (0.37) | CRHR1NR4A2 | |
| Hydrochloric Acid SCHEMBL7624850 | 0.78 | LMNA (0.34) | HCAR3CRHR1MAPTTDP1L3MBTL1 | |
| SCHEMBL23530034 | 0.78 | NR4A2 (0.43) | HCAR3MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL7222310 | 0.78 | LMNA (0.33) | HCAR3MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL7224417 | 0.78 | LMNA (0.33) | HCAR3MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL7480289 | 0.78 | NR4A2 (0.45) | HCAR3MAPTPOLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448261-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS; TREATING ANXIETY, DEPRESSION, AND OTHER PSYCHIATRIC AND NEUROLOGICAL DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-09-10 | — | — | US | disclosed |
| EP-0935601-A4 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARM CO (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6107300-A | CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS (US) | 2000-08-22 | — | — | US | disclosed |
| CN-1230184-A | Arylamino fused pyridines and pyrimidines | DU PONT MERCK PHARMA (US) | 1999-09-29 | — | — | CN | disclosed |
| EP-0935601-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | Du Pont Pharmaceuticals Company (US) | 1999-08-18 | — | — | EP | disclosed |
| WO-1997035539-A2 | ARYLAMINO FUSED PYRIDINES AND PYRIMIDINES | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |