Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 3/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476339 | 0.85 | MAPT (0.67) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7481013 | 0.82 | MAPT (0.63) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7478376 | 0.79 | MAPT (0.65) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7483095 | 0.79 | MAPT (0.67) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7479019 | 0.77 | RAB9A (0.61) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7477859 | 0.77 | MAPT (0.64) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7421558 | 0.77 | MAPT (0.56) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7478008 | 0.76 | MAPT (0.63) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7429393 | 0.76 | RAB9A (0.59) | MAPTTP53RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3467894 | 0.73 | MEN1 (0.62) | MAPTRAB9ASMN1; SMN2ABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |