Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486259 | 0.78 | GABRA1 (0.49) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL7478081 | 0.74 | RXFP1 (0.52) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL31058084 | 0.72 | GABRA1 (0.58) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL1258627 | 0.72 | GABRA1 (0.58) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL21362800 | 0.72 | GABRG2 (0.50) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL7451922 | 0.71 | RXFP1 (0.58) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL7957849 | 0.71 | LMNA (0.72) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL7479344 | 0.70 | RXFP1 (0.57) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL7480128 | 0.70 | RXFP1 (0.57) | RXFP1L3MBTL1LMNAGABRG2GABRB3 | |
| SCHEMBL18973197 | 0.70 | RXFP1 (0.57) | RXFP1L3MBTL1LMNAGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986562-B1 | SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME (GB) | 2002-08-07 | — | — | EP | disclosed |
| US-6200975-B1 | FOR COGNITION ENHANCEMENT THERAPY | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-13 | — | — | US | disclosed |