SCHEMBL7480860

SCHEMBL7480860

O=C1c2ccccc2C(=O)N1NCc1ccncc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.56
TSHR P16473 2/20 0.54
LMNA P02545 2/20 0.51
ALDH1A1 P00352 5/20 0.43
CYP1A2 P05177 2/20 0.42
KCNQ2 O43526 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
ALOX15 P16050 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
MAPT P10636 2/20 0.41
GAA P10253 1/20 0.41
HTT P42858 2/20 0.41
KDM4E B2RXH2 2/20 0.41
ADRA2C P18825 2/20 0.41
HSD17B10 Q99714 1/20 0.40
KCNA5 P22460 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2036237 0.85 L3MBTL1 (0.54) LMNAALDH1A1CYP1A2L3MBTL1MEN1
SCHEMBL29115326 0.82 SMN1; SMN2 (0.44) SMN1; SMN2TSHRLMNAALDH1A1ALOX15
SCHEMBL7481564 0.82 STAT3 (0.45) SMN1; SMN2TSHRLMNAALDH1A1GAA
Hydrochloric Acid SCHEMBL7475918 0.79 STAT3 (0.43) SMN1; SMN2TSHRLMNAALDH1A1GAA
Hydrochloric Acid SCHEMBL7475915 0.79 STAT3 (0.43) SMN1; SMN2TSHRLMNAALDH1A1GAA
SCHEMBL7485009 0.73 CYP1A2 (0.71) SMN1; SMN2LMNAALDH1A1CYP1A2L3MBTL1
SCHEMBL6165776 0.73 CASP3 (0.62) SMN1; SMN2TSHRALDH1A1MEN1KMT2A
SCHEMBL11887860 0.70 TSHR (1.00) SMN1; SMN2TSHRALDH1A1CYP1A2CYP3A4
SCHEMBL4633333 0.70 GRM5 (0.66) SMN1; SMN2TSHRALDH1A1L3MBTL1KMT2A
SCHEMBL4887193 0.70 GABRA5 (0.44) LMNAALDH1A1CYP1A2CYP2C9MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0950056-B1 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS AVENTIS PHARMA INC (US) 2002-09-18 EP disclosed
US-6004977-A ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0950056-A2 N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS HOECHST MARION ROUSSEL, INC. (US) 1999-10-20 EP disclosed
WO-1998029407-A2 N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION HOECHST MARION ROUSSEL, INC. (US) 1998-07-09 WO disclosed