SCHEMBL7483549

SCHEMBL7483549

CN(Cc1ccc(Cl)cc1)C(=O)c1n[nH]c2ccc(CO)cc2c1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.44
RAB9A P51151 2/20 0.40
ALDH1A1 P00352 1/20 0.40
HTT P42858 1/20 0.40
NR1H4 Q96RI1 1/20 0.40
NPC1 O15118 1/20 0.40
PRKAB2 O43741 1/20 0.39
PRKAG1 P54619 1/20 0.39
PRKAA2 P54646 1/20 0.39
PRKAA1 Q13131 1/20 0.39
PRKAG3 Q9UGI9 1/20 0.39
PRKAG2 Q9UGJ0 1/20 0.39
PRKAB1 Q9Y478 1/20 0.39
MEN1 O00255 1/20 0.39
GAA P10253 1/20 0.39
KMT2A Q03164 1/20 0.39
ITK Q08881 1/20 0.38
TTK P33981 1/20 0.38
HAT1 O14929 1/20 0.37
EP300 Q09472 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6672645 0.90 HSP90AA1 (0.42) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL6667497 0.89 HSP90AA1 (0.41) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL7475445 0.88 HSP90AA1 (0.44) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL6671405 0.87 HSP90AA1 (0.40) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL6672009 0.83 HSP90AA1 (0.39) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL6667774 0.83 CHEK1 (0.46) HSP90AA1RAB9AALDH1A1NR1H4NPC1
SCHEMBL7015592 0.81 HSP90AA1 (0.40) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL7845846 0.79 GAA (0.51) ALDH1A1HTTGAA
SCHEMBL7014636 0.77 RAB9A (0.38) HSP90AA1RAB9AALDH1A1HTTNR1H4
SCHEMBL7015761 0.76 ALDH1A1 (0.41) HSP90AA1RAB9AALDH1A1HTTNR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1265873-A2 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2002-12-18 EP disclosed
WO-2001070706-A2 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2001-09-27 WO disclosed