SCHEMBL7484099

SCHEMBL7484099

CCC(=O)c1nsc2nc3ccccc3n12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 0.43
MAPK1 P28482 3/20 0.41
SMN1; SMN2 Q16637 5/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
TP53 P04637 1/20 0.41
ALDH1A1 P00352 3/20 0.41
RECQL P46063 1/20 0.41
USP2 O75604 1/20 0.41
LMNA P02545 1/20 0.40
MAPT P10636 3/20 0.40
KDM4E B2RXH2 3/20 0.40
MEN1 O00255 1/20 0.40
GAA P10253 1/20 0.40
KMT2A Q03164 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
TLR9 Q9NR96 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7484824 0.89 HPGD (0.44) MAPK1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL7486338 0.84 KDM4E (0.47) ADORA3MAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL7486359 0.83 NPC1 (0.45) ADORA3MAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL7486172 0.82 KDM4E (0.53) SMN1; SMN2NPC1RAB9ATP53ALDH1A1
SCHEMBL7483925 0.82 KDM4E (0.43) MAPK1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL8034975 0.81 KDM4E (0.42) MAPK1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL7485473 0.80 ALDH1A1 (0.49) ADORA3MAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL7474964 0.79 HSD17B10 (0.44) MAPK1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL7474025 0.79 CA12 (0.42) MAPK1SMN1; SMN2NPC1RAB9ATP53
SCHEMBL7469069 0.78 MAOA (0.51) ADORA3SMN1; SMN2NPC1RAB9ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0883622-B1 PROTON PUMP INHIBITOR APOTEX INC (CA) 2002-05-15 EP disclosed
US-6114537-A 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS APOTEX INC. (CA) 2000-09-05 US disclosed
US-6093738-A IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT KARIMIAN KHASHAYAR (CA) 2000-07-25 US disclosed
US-5677302-A Thiadiazole compounds useful as proton pump inhibitors APOTEX INC. (CA) 1997-10-14 US disclosed