Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479695 | 0.88 | TSHR (0.46) | KDM4ERAB9AHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL7485473 | 0.85 | ALDH1A1 (0.49) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7479483 | 0.85 | TDP1 (0.43) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7484099 | 0.82 | ADORA3 (0.43) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7481366 | 0.82 | MEN1 (0.44) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7486338 | 0.80 | KDM4E (0.47) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7484824 | 0.80 | HPGD (0.44) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7479334 | 0.80 | KDM4E (0.46) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7483925 | 0.79 | KDM4E (0.43) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL8034975 | 0.77 | KDM4E (0.42) | KDM4ERAB9AHSD17B10HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883622-B1 | PROTON PUMP INHIBITOR | APOTEX INC (CA) | 2002-05-15 | — | — | EP | disclosed |
| US-6114537-A | 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS | APOTEX INC. (CA) | 2000-09-05 | — | — | US | disclosed |
| US-6093738-A | IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT | KARIMIAN KHASHAYAR (CA) | 2000-07-25 | — | — | US | disclosed |
| US-5677302-A | Thiadiazole compounds useful as proton pump inhibitors | APOTEX INC. (CA) | 1997-10-14 | — | — | US | disclosed |