Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483925 | 0.98 | KDM4E (0.43) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7469069 | 0.85 | MAOA (0.51) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7486338 | 0.84 | KDM4E (0.47) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7474964 | 0.83 | HSD17B10 (0.44) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7486359 | 0.81 | NPC1 (0.45) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7484099 | 0.81 | ADORA3 (0.43) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7485473 | 0.81 | ALDH1A1 (0.49) | KDM4EHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7484824 | 0.79 | HPGD (0.44) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7485791 | 0.79 | MAOA (0.40) | KDM4EHSD17B10MEN1KMT2ANPC1 | |
| SCHEMBL7485787 | 0.79 | MAOA (0.40) | KDM4EHSD17B10MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114537-A | 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS | APOTEX INC. (CA) | 2000-09-05 | — | — | US | disclosed |
| EP-0883606-A1 | PROCESS FOR SCAVENGING THIOLS | APOTEX INC. (CA) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997031893-A1 | PROCESS FOR SCAVENGING THIOLS | APOTEX INC. (CA) | 1997-09-04 | — | — | WO | disclosed |