Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 8/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 16/20 | 0.58 |
| ▸ | MMP9 | P14780 | 16/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 7/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551651 | 0.82 | MMP2 (0.56) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL7474147 | 0.82 | MMP2 (0.64) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL8551832 | 0.81 | MMP8 (0.65) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL27491360 | 0.81 | MMP8 (0.69) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL7474462 | 0.80 | MMP8 (0.64) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL28614818 | 0.79 | BRD4 (0.54) | MMP8MMP3MMP2MMP9GRIN1 | |
| SCHEMBL8555925 | 0.79 | MMP8 (0.62) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL7483511 | 0.79 | MMP2 (0.52) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL7476592 | 0.77 | MMP2 (0.80) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL8553779 | 0.77 | MMP2 (0.61) | MMP8MMP3MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | claimed |
| CN-1318406-C | New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same | BOEHRINGER MANNHEIM GMBH (DE) | 2007-05-30 | — | — | CN | disclosed |
| US-6472396-B1 | Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-29 | — | — | US | disclosed |
| EP-0869947-B1 | BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-23 | — | — | EP | disclosed |
| US-6110924-A | MATRIX METALLOPROTEASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-08-29 | — | — | US | disclosed |
| CN-1209123-A | New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same | BOEHRINGER MANNHEIM GMBH (DE) | 1999-02-24 | — | — | CN | disclosed |
| EP-0869947-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023465-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-07-03 | — | — | WO | disclosed |