Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | MAT2A | P31153 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484296 | 1.00 | KCNH2 (0.47) | KCNH2MAT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL16268176 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2HPGDLMNAKDM4EALDH1A1 | |
| SCHEMBL15362055 | 0.81 | HPGD (0.50) | KCNH2MAT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL15362054 | 0.81 | HPGD (0.50) | KCNH2MAT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL6549648 | 0.81 | ALDH1A1 (0.48) | KCNH2MAT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL2030928 | 0.75 | NFE2L2 (0.35) | KCNH2MAT2A | |
| SCHEMBL2030929 | 0.75 | NFE2L2 (0.35) | KCNH2MAT2A | |
| SCHEMBL16067619 | 0.75 | KCNH2 (0.56) | KCNH2MAT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL17458649 | 0.75 | KCNH2 (0.56) | KCNH2MAT2ASMN1; SMN2HPGDLMNA | |
| SCHEMBL7902449 | 0.74 | TRPA1 (0.38) | LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1166638-C | Novel benzo-[3,4] cyclobutano [1,2-C] pyrroles compound, its prepn. and medicine composition containing the same | ɪά��ʵ���� | 2004-09-15 | — | — | CN | disclosed |
| EP-1038873-B1 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | SERVIER LAB (FR) | 2002-05-02 | — | — | EP | disclosed |
| CN-1274718-A | Novel benzo-[3,4] cyclobutano [1,2-C] pyrroles compound, its prepn. and medicine composition containing the same | ADIR (FR) | 2000-11-29 | — | — | CN | disclosed |
| US-6153640-A | FOR TREATING DEPRESSION, PANIC ATTACKS, OBSESSIVE-COMPULSIVE DISORDERS, PHOBIAS, IMPULSIVE DISORDERS, DRUG ABUSE OR ANXIETY | ADIR ET COMPAGNIE (FR) | 2000-11-28 | — | — | US | disclosed |
| EP-1038873-A2 | Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives as inhibitors of serotonine reuptake | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |