Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488242 | 0.90 | MAPT (0.53) | MAPTGAAPOLBALDH1A1HPGD | |
| SCHEMBL7493208 | 0.87 | SLC10A2 (0.50) | MAPTABCG2GAAALDH1A1KDM4E | |
| SCHEMBL7485972 | 0.87 | MAPT (0.53) | MAPTABCG2GAAPOLBALDH1A1 | |
| Diethylamine SCHEMBL7485977 | 0.83 | ABCG2 (0.66) | MAPTABCG2GAAPOLBALDH1A1 | |
| SCHEMBL7494845 | 0.81 | PRKCI (0.48) | MAPTPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL7494813 | 0.78 | MAPT (0.44) | MAPTGAAPOLBALDH1A1HPGD | |
| SCHEMBL7484252 | 0.78 | MAPT (0.49) | MAPTABCG2POLBALDH1A1KDM4E | |
| SCHEMBL7490064 | 0.77 | POLB (0.44) | MAPTGAAPOLBALDH1A1HPGD | |
| SCHEMBL8806198 | 0.76 | ALDH1A1 (0.44) | MAPTGAAPOLBALDH1A1HPGD | |
| SCHEMBL7485921 | 0.75 | SLC10A2 (0.48) | MAPTABCG2GAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791000-B1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5747486-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0791000-A1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996014319-A1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-17 | — | — | WO | disclosed |