Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485233 | 0.90 | MAPT (0.56) | MAPTKDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7494813 | 0.88 | MAPT (0.44) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7484252 | 0.88 | MAPT (0.49) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7490064 | 0.86 | POLB (0.44) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8806198 | 0.85 | ALDH1A1 (0.44) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7493208 | 0.85 | SLC10A2 (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2HTT | |
| Diethylamine SCHEMBL7494820 | 0.83 | CYP2C9 (0.52) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7490926 | 0.83 | CYP2C9 (0.42) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7494845 | 0.83 | PRKCI (0.48) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7485972 | 0.77 | MAPT (0.53) | MAPTKDM4EALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791000-B1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5747486-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0791000-A1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996014319-A1 | THIENOPYRIDINE OR THIENOPYRIMIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-17 | — | — | WO | disclosed |