Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.55 |
| ▸ | CTSS | P25774 | 12/20 | 0.55 |
| ▸ | CTSB | P07858 | 11/20 | 0.55 |
| ▸ | CTSL | P07711 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540238 | 0.91 | CTSK (0.58) | CTSKCTSSCTSBCTSLNPC1 | |
| SCHEMBL6184317 | 0.90 | CTSS (0.56) | CTSKCTSSCTSBCTSL | |
| SCHEMBL6181105 | 0.86 | CTSK (0.71) | CTSKCTSSCTSBCTSL | |
| SCHEMBL7536506 | 0.85 | CTSK (0.44) | CTSKCTSSCTSBCTSL | |
| SCHEMBL6183387 | 0.83 | CTSK (0.60) | CTSKCTSSCTSBCTSL | |
| SCHEMBL7606091 | 0.83 | CTSK (0.60) | CTSKCTSSCTSBCTSL | |
| SCHEMBL7489115 | 0.83 | CTSB (0.46) | CTSKCTSSCTSBCTSLNPC1 | |
| SCHEMBL6185994 | 0.82 | CTSB (0.54) | CTSKCTSSCTSBCTSLNPC1 | |
| SCHEMBL7450076 | 0.82 | CTSB (0.54) | CTSKCTSSCTSBCTSLNPC1 | |
| SCHEMBL7450318 | 0.82 | CTSB (0.54) | CTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001068645-A2 | N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-09-20 | — | — | WO | claimed |
| EP-1161415-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2001068645-A2 | N-CYANOMETHYLCARBOXAMIDES AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000055126-A2 | N-CYANOMETHYLAMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |