SCHEMBL7486408

SCHEMBL7486408

Cc1ccccc1N(c1ccc(N(c2ccc(N(c3ccc(N(c4ccccc4C)c4ccccc4C)cc3)c3ccc(N(c4ccccc4C)c4ccccc4C)cc3)cc2)c2ccc(N(c3ccccc3C)c3ccccc3C)cc2)cc1)c1ccccc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.43
TSHR P16473 2/20 0.43
ALDH1A1 P00352 6/20 0.41
CYP3A4 P08684 4/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KDM4E B2RXH2 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
LMNA P02545 3/20 0.38
SIGMAR1 Q99720 1/20 0.36
APP P05067 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8943789 0.97 ACHE (0.45) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL4893894 0.95 ACHE (0.43) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL15247033 0.93 ALDH1A1 (0.46) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL13929896 0.91 ACHE (0.39) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL7154196 0.91 ACHE (0.39) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL13480247 0.91 TSHR (0.42) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL3477596 0.91 ALDH1A1 (0.48) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL8470149 0.90 TSHR (0.43) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL185396 0.89 CYP3A4 (0.43) ACHETSHRALDH1A1CYP3A4L3MBTL1
SCHEMBL1153906 0.89 CYP3A4 (0.43) ACHETSHRALDH1A1CYP3A4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0818512-B1 Quinoline derivative and use of same MITSUI CHEMICALS INC (JP) 2002-10-02 EP disclosed
US-6407242-B1 REACTING A PHTHALIMIDE COMPOUND WITH A QUINOLINE COMPOUND;ELECTROLUMINESCENCE MITSUI CHEMICALS, INC. (JP) 2002-06-18 US disclosed
US-6132640-A ZINC COMPLEXES OF QUINOLINE MITSUI CHEMICALS, INC. (JP) 2000-10-17 US disclosed
EP-0818512-A1 Quinoline derivative and use of same MITSUI TOATSU CHEMICALS, Inc. (JP) 1998-01-14 EP disclosed