Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL28014688 | 0.90 | TSHR (0.35) | CYP2C9TSHRCYP2C19MTORHRH4 | |
| Histamine SCHEMBL2134035 | 0.89 | TDP1 (0.38) | LMNACYP2C9TSHRCYP2C19MTOR | |
| Histamine SCHEMBL1782847 | 0.88 | HRH4 (0.36) | LMNACYP2C9TSHRCYP2C19MTOR | |
| Histamine SCHEMBL27177427 | 0.87 | TDP1 (0.37) | LMNACYP2C9TSHRCYP2C19MTOR | |
| Histamine SCHEMBL4234179 | 0.86 | HRH4 (0.39) | LMNACYP2C9TSHRCYP2C19MTOR | |
| Histamine SCHEMBL8887482 | 0.85 | HRH4 (0.34) | CYP2C9TSHRCYP2C19MTORHRH4 | |
| Histamine SCHEMBL5840054 | 0.85 | HRH4 (0.38) | CYP2C9TSHRCYP2C19MTORHRH4 | |
| Histamine SCHEMBL5321413 | 0.83 | LMNA (0.33) | LMNACYP2C9TSHRCYP2C19MTOR | |
| Histamine SCHEMBL1680140 | 0.83 | LMNA (0.33) | LMNACYP2C9TSHRCYP2C19MTOR | |
| Histamine SCHEMBL5171138 | 0.83 | LMNA (0.38) | LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115298535-A | Detectable arrays for distinguishing analytes and diagnostics and methods and systems related thereto | 恩拓普斯有限公司 | 2022-11-04 | — | — | CN | claimed |
| EP-4022284-A1 | DETECTABLE ARRAYS FOR DISTINGUISHING ANALYTES AND DIAGNOSIS, AND METHODS AND SYSTEMS RELATED THERETO | Entopsis, Inc. (US) | 2022-07-06 | — | — | EP | claimed |
| WO-2021042063-A1 | DETECTABLE ARRAYS FOR DISTINGUISHING ANALYTES AND DIAGNOSIS, AND METHODS AND SYSTEMS RELATED THERETO | Entopsis, LLC (US) | 2021-03-04 | — | — | WO | claimed |
| US-20160274103-A1 | DETECTABLE ARRAYS, SYSTEMS FOR DIAGNOSIS, AND METHODS OF MAKING AND USING THE SAME | ENTOPSIS (US) | 2016-09-22 | — | — | US | claimed |
| EP-3049560-A1 | DETECTABLE ARRAYS, SYSTEMS FOR DIAGNOSIS, AND METHODS OF MAKING AND USING THE SAME | Entopsis (US) | 2016-08-03 | — | — | EP | claimed |
| CN-105556007-A | Detectable arrays, systems for diagnosis, and methods of making and using the same | ENTOPSIS | 2016-05-04 | — | — | CN | claimed |
| WO-2015047958-A1 | DETECTABLE ARRAYS, SYSTEMS FOR DIAGNOSIS, AND METHODS OF MAKING AND USING THE SAME | ENTOPSIS (US) | 2015-04-02 | — | — | WO | claimed |
| CN-100339405-C | Liquid-absorbing sheet and nonaqueous electrolyte battery case | SONY CHEMICALS (JP) | 2007-09-26 | — | — | CN | claimed |
| CN-1324402-C | Photosensitive resin composition and photosensitive films and laminates made by using the same | KANEGAFUCHI CHEMICAL IND (JP) | 2007-07-04 | — | — | CN | claimed |
| CN-1751073-A | Liquid absorbing sheet and non-aqueous electrolyte battery pack | SONY CHEMICALS (JP) | 2006-03-22 | — | — | CN | claimed |
| US-20230392031-A1 | INK COMPOSITION | DNP FINE CHEMICALS CO., LTD. (JP) | 2023-12-07 | — | — | US | disclosed |
| EP-4238770-A1 | INK COMPOSITION | DNP Fine Chemicals Co., Ltd. (JP) | 2023-09-06 | — | — | EP | disclosed |
| EP-4215551-A1 | CURABLE COMPOSITION, INK FOR SOLDER RESIST, AND PRINTED CIRCUIT BOARD | KONICA MINOLTA, INC. (JP) | 2023-07-26 | — | — | EP | disclosed |
| CN-115917427-A | Transparent screen for water tank, water tank and transparent image display system | 富士胶片株式会社 | 2023-04-04 | — | — | CN | disclosed |
| US-20220398733-A1 | DETECTABLE ARRAYS FOR DISTINGUISHING ANALYTES AND DIAGNOSIS, AND METHODS AND SYSTEMS RELATED THERETO | ENTOPSIS, INC. | 2022-12-15 | — | — | US | disclosed |
| CN-1751073-A | Liquid absorbing sheet and non-aqueous electrolyte battery pack | SONY CHEMICALS (JP) | 2006-03-22 | — | — | CN | disclosed |
| EP-1043313-B1 | ACTINIC RADIATION-CURABLE ACRYLATE COMPOSITIONS | TOAGOSEI CO LTD (JP) | 2005-06-08 | — | — | EP | disclosed |
| CN-1599884-A | Photosensitive resin composition and photosensitive films and laminates made by using the same | KANEGAFUCHI CHEMICAL IND (JP) | 2005-03-23 | — | — | CN | disclosed |
| US-6329443-B1 | TO FORM CURED COMPOSITIONS EXCELLENT IN WEATHER RESISTANCE, ABRASION RESISTANCE AND ADHESION TO A BASE, AND FREE FROM OF ODOR | TOAGOSEI CO, LTD. (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1043313-A1 | NEW ACRYLATES AND ACTINIC RADIATION-CURABLE COMPOSITIONS CONTAINING THEM | Toagosei Co., Ltd. (JP) | 2000-10-11 | — | — | EP | disclosed |