Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.57 |
| ▸ | MMP2 | P08253 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 7/20 | 0.49 |
| ▸ | MMP1 | P03956 | 6/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6321605 | 1.00 | MMP9 (0.57) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL6323674 | 0.89 | MMP9 (0.60) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL6323932 | 0.86 | TAS2R14 (0.62) | ALDH1A1CXCR3LMNAPTGESTAS2R14 | |
| SCHEMBL6326217 | 0.83 | MMP9 (0.57) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL26770427 | 0.81 | ALDH1A1 (0.73) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL6321598 | 0.80 | MMP9 (0.63) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL6321600 | 0.80 | MMP9 (0.63) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL26770391 | 0.80 | MMP9 (0.55) | MMP9MMP2ALDH1A1CXCR3PDE4A | |
| SCHEMBL1169467 | 0.78 | TAS2R14 (0.79) | ALDH1A1CXCR3PTGESTAS2R14TAS2R8 | |
| SCHEMBL7340409 | 0.78 | ALDH1A1 (0.75) | MMP9MMP2ALDH1A1CXCR3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939629-A4 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0939629-A1 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003166-A1 | THIOL SULFONAMIDE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |