SCHEMBL7340409

SCHEMBL7340409

COc1ccc(S(=O)(=O)N(CC(=O)NO)Cc2cccnc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.75
MMP9 P14780 8/20 0.74
MMP13 P45452 7/20 0.74
ADAM17 P78536 5/20 0.74
MMP1 P03956 5/20 0.74
MMP2 P08253 3/20 0.67
MEP1B Q16820 2/20 0.67
ADAM10 O14672 1/20 0.67
MEP1A Q16819 1/20 0.67
MMP3 P08254 3/20 0.66
BMP1 P13497 3/20 0.63
MMP7 P09237 1/20 0.60
MMP8 P22894 1/20 0.60
MMP12 P39900 1/20 0.60
CXCR3 P49682 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13898980 0.89 MMP9 (0.70) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL26771428 0.89 MMP9 (0.62) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL8455467 0.88 MMP9 (0.70) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL26770427 0.88 ALDH1A1 (0.73) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL26770051 0.87 MMP9 (0.67) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL7421418 0.87 BMP1 (0.74) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL8457085 0.87 MMP13 (0.73) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL7338644 0.87 MEP1B (0.81) ALDH1A1MMP9MMP13ADAM17MMP1
SCHEMBL2515822 0.86 MMP9 (0.72) ALDH1A1MMP9MMP13ADAM17MMP1
Hydrochloric Acid SCHEMBL7350033 0.86 BMP1 (0.73) ALDH1A1MMP9MMP13ADAM17MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020252439-A1 CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE AGENTS FOR BORON NEUTRON CAPTURE THERAPY LOYOLA UNIVERSITY OF CHICAGO (US) 2020-12-17 WO disclosed
EP-2520573-A1 Compounds with matrix-metalloproteinase inhibitory activity Westfälische Wilhelms-Universität Münster (DE) 2012-11-07 EP disclosed
EP-0766672-B1 ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS NOVARTIS AG (CH) 2000-10-04 EP disclosed
EP-0606046-B1 Arylsulfonamido-substituted hydroxamic acids CIBA GEIGY AG (CH) 1997-10-08 EP disclosed
US-5646167-A ADMINISTERED AS METALLOPROTEINASE INHIBITOR, ANTITUMOR OR ANTICARCINOGENIC AGENT CIBA-GEIGY CORPORATION (US) 1997-07-08 US disclosed
EP-0766672-A1 ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS Novartis AG (CH) 1997-04-09 EP disclosed
WO-1996040101-A1 CERTAIN ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS FOR THE TREATMENT OF CERTAIN TUMORS NOVARTIS AG (CH) 1996-12-19 WO disclosed
US-5552419-A METALLOPROTEINASE INHIBITORS CIBA-GEIGY CORPORATION (US) 1996-09-03 US disclosed
US-5506242-A METALLOELASTASE INHIBITOR; TREATS EMPHYSEMA CIBA-GEIGY CORPORATION (US) 1996-04-09 US disclosed
WO-1996000214-A1 ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS CIBA-GEIGY AG (CH) 1996-01-04 WO disclosed
US-5455258-A Useful as inhibitors of matrix-degrading metalloproteinase enzymes such as stromelysin and/or collegenase CIBA-GEIGY CORPORATION (US) 1995-10-03 US disclosed
EP-0606046-A1 Arylsulfonamido-substituted hydroxamic acids CIBA-GEIGY AG (CH) 1994-07-13 EP disclosed