Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 5/20 | 0.38 |
| ▸ | CCR8 | P51685 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085950 | 0.73 | TOP1 (0.37) | HSP90AA1LMNACCR1CCR8HTT | |
| SCHEMBL1773094 | 0.71 | PRMT5 (0.53) | PRMT5L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL35643 | 0.71 | ELANE (0.33) | PRMT5L3MBTL1NPC1LMNAMAPT | |
| SCHEMBL411657 | 0.69 | CYP1A2 (0.45) | L3MBTL1LMNAKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL16626083 | 0.67 | PRMT5 (0.49) | PRMT5L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL1926880 | 0.67 | LMNA (0.48) | PRMT5L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL8284604 | 0.67 | PRMT5 (0.68) | PRMT5L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL9058058 | 0.67 | KDM4E (0.50) | PRMT5L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL435004 | 0.64 | MAPT (0.54) | PRMT5L3MBTL1HSP90AA1NPC1LMNA | |
| SCHEMBL29832653 | 0.64 | MAPT (0.54) | PRMT5L3MBTL1HSP90AA1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204663-A1 | NOVEL SPIRO COMPOUNDS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001014376-A1 | NOVEL SPIRO COMPOUNDS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2001-03-01 | — | — | WO | disclosed |