Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24363088 | 0.74 | TOP1 (0.41) | TOP1SLC40A1MEN1TNFCXCL8 | |
| SCHEMBL29631939 | 0.74 | TOP1 (0.41) | TOP1SLC40A1MEN1TNFCXCL8 | |
| SCHEMBL22372352 | 0.74 | PARP1 (0.38) | BACE1CYP2D6 | |
| SCHEMBL7487342 | 0.73 | PRMT5 (0.47) | MEN1KMT2AKDM4EGMNNLMNA | |
| SCHEMBL20526115 | 0.73 | BACE1 (0.51) | MEN1KMT2ABACE1KDM4EKIF11 | |
| SCHEMBL10840576 | 0.68 | MAPT (0.48) | SLC40A1MEN1TNFCXCL8KMT2A | |
| SCHEMBL27964544 | 0.67 | SLC40A1 (0.46) | TOP1SLC40A1MEN1TNFCXCL8 | |
| SCHEMBL2569765 | 0.64 | PSMD14 (0.55) | SLC40A1KDM4EGMNNLMNATP53 | |
| SCHEMBL29935933 | 0.64 | PSMD14 (0.55) | SLC40A1KDM4EGMNNLMNATP53 | |
| Quinoline SCHEMBL28226310 | 0.64 | ALDH1A1 (0.57) | TOP1SLC40A1MEN1TNFCXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220499-A1 | Novel spiro compounds | MSD K.K. (JP) | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220499-A1 | Novel spiro compounds | NPY1R, OPRK1, OPRM1 | TOP1 2327/4885SLC40A1 3335/4885MEN1 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.