Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GNG2 | P59768 | 1/20 | 0.44 |
| ▸ | GNB1 | P62873 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487677 | 0.86 | TP53 (0.52) | TP53KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL7486918 | 0.82 | ALDH1A1 (0.60) | TP53KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL7830913 | 0.77 | CNR2 (0.47) | KDM4EALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL5423338 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL7830713 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1MAPTHSD17B10HPGD | |
| SCHEMBL5426108 | 0.76 | NOTUM (0.65) | ALDH1A1MAPTHPGDTSHRPOLB | |
| SCHEMBL10856983 | 0.76 | NOTUM (0.56) | TP53KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8790990 | 0.75 | TP53 (0.52) | TP53KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL5423637 | 0.74 | PDK1 (0.49) | TP53KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL14500666 | 0.74 | ALDH1A1 (0.49) | KDM4EALDH1A1MAPTHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065204-B1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6303628-B1 | FOR THE TREATMENT OF A MEDICAL CONDITION IN WHICH PROSTAGLANDINS ARE IMPLICATED AS PATHOGENS IN MAMMALS | PFIZER INC | 2001-10-16 | — | — | US | disclosed |
| EP-1065204-A1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |