Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL27857769 | 0.70 | TP53 (0.41) | TP53TSHRHPGDMEN1KMT2A | |
| SCHEMBL6333046 | 0.70 | LMNA (0.44) | TP53TSHRHPGDMEN1KMT2A | |
| SCHEMBL4027334 | 0.70 | LMNA (0.46) | MEN1KMT2A | |
| SCHEMBL7866581 | 0.68 | TP53 (0.39) | TP53TSHRHPGDMEN1KMT2A | |
| SCHEMBL6159422 | 0.64 | — | — | |
| SCHEMBL1259804 | 0.64 | — | — | |
| SCHEMBL2214936 | 0.64 | — | — | |
| SCHEMBL5090054 | 0.64 | LTA4H (0.42) | TP53TSHRHPGDKMT2A | |
| SCHEMBL27512119 | 0.64 | LTA4H (0.42) | TP53TSHRHPGDKMT2A | |
| SCHEMBL27910344 | 0.63 | TP53 (0.53) | TP53TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261601-A1 | SUBSTITUTED INDOLES FOR MODULATING NFKB ACTIVITY | Aventis Pharma Deutschland GmbH (DE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001030774-A1 | SUBSTITUTED INDOLES FOR MODULATING NFKB ACTIVITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-05-03 | — | — | WO | disclosed |