Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485995 | 0.78 | HTR1A (0.54) | HRH3HRH1HTR7DRD2DRD3 | |
| SCHEMBL7488037 | 0.78 | HTR1A (0.53) | HRH3HRH1HTR7DRD2DRD3 | |
| SCHEMBL7491899 | 0.77 | HTR1A (0.54) | DRD2HTR1A | |
| SCHEMBL1714405 | 0.76 | HRH3 (0.74) | HRH3HRH1DRD2DRD3HTR1A | |
| SCHEMBL7483822 | 0.76 | HRH3 (0.42) | HRH3HRH1HTR7DRD2HTR1A | |
| SCHEMBL14761486 | 0.76 | DRD2 (0.60) | HRH1HTR7DRD2DRD3HTR1A | |
| SCHEMBL7484406 | 0.76 | HRH3 (0.42) | HRH3DRD2DRD3HTR1A | |
| SCHEMBL6135057 | 0.75 | HRH3 (0.57) | HRH3HRH1HTR7DRD2DRD3 | |
| SCHEMBL6135382 | 0.75 | HRH3 (0.57) | HRH3HRH1HTR7DRD2DRD3 | |
| SCHEMBL6135083 | 0.75 | HRH3 (0.57) | HRH3HRH1HTR7DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | claimed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | claimed |
| EP-1023287-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2000-08-02 | — | — | EP | claimed |
| WO-1999020622-A1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 1999-04-29 | — | — | WO | claimed |
| EP-1023287-B1 | 3-OXO-2(H)-1,2,4-TRIAZINE DERIVATIVES AS LIGANDS OF 5HT1A RECEPTORS | PF MEDICAMENT (FR) | 2002-06-12 | — | — | EP | disclosed |
| US-6303603-B1 | FOR THEARPY OF ANXIETY, DEPRESSION, SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-10-16 | — | — | US | disclosed |