Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923639 | 0.83 | NR1I2 (0.33) | CHRNA7POLBNR1I2ALDH1A1 | |
| SCHEMBL181548 | 0.69 | MEN1 (0.47) | POLBCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL10722541 | 0.68 | ALDH1A1 (0.47) | CYP1A2CYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL27464474 | 0.67 | NR1I2 (0.39) | CHRNA7POLBNR1I2MEN1ALDH1A1 | |
| SCHEMBL9767962 | 0.66 | MEN1 (0.37) | POLBMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6515952 | 0.64 | CHRNA7 (0.31) | CHRNA7NR1I2PKM | |
| SCHEMBL8513034 | 0.64 | MAPT (0.47) | MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL10447250 | 0.64 | GAA (0.42) | POLBCYP1A2CYP2D6MEN1ALDH1A1 | |
| SCHEMBL5159834 | 0.64 | F2 (0.43) | CYP1A2MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8496732 | 0.64 | CHRNA7 (0.42) | CHRNA7NR1I2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |