Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 10/20 | 0.41 |
| ▸ | MAOB | P27338 | 10/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971020 | 0.76 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL2321708 | 0.76 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL12844164 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL14736417 | 0.73 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL12775968 | 0.73 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| Hydrochloric Acid SCHEMBL14736655 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL2226979 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL9229324 | 0.71 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL14736416 | 0.70 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMAPTOPRK1 | |
| SCHEMBL2093741 | 0.69 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643050-B1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-5614544-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |