Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 6/20 | 0.51 |
| ▸ | MAOB | P27338 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | RARG | P13631 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formamide SCHEMBL28723243 | 0.89 | ALDH1A1 (0.50) | ALDH1A1HPGDNTRK1MAOAMAOB | |
| SCHEMBL7951904 | 0.83 | ALDH1A1 (0.65) | ALDH1A1HPGDMEN1MAPTKMT2A | |
| SCHEMBL12618487 | 0.83 | RARA (0.65) | ALDH1A1MAOAMAOBMEN1MAPT | |
| SCHEMBL2096231 | 0.81 | RARA (0.73) | ALDH1A1MAOAMAOBMEN1MAPT | |
| SCHEMBL3763258 | 0.81 | MAOA (0.50) | ALDH1A1MAOAMAOBMEN1MAPT | |
| SCHEMBL8472083 | 0.81 | ALDH1A1 (0.58) | ALDH1A1HPGDNTRK1MAOAMAOB | |
| SCHEMBL526264 | 0.81 | PTGS2 (0.69) | ALDH1A1HPGDNTRK1MEN1MAPT | |
| SCHEMBL8202097 | 0.80 | ALDH1A1 (0.49) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL543809 | 0.79 | NTRK1 (0.51) | ALDH1A1HPGDNTRK1MEN1MAPT | |
| SCHEMBL22650293 | 0.79 | NTRK1 (0.51) | ALDH1A1HPGDNTRK1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799871-B1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOTOTIC BAX | DANA FARBER CANCER INST INC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-11771738-B2 | Endoparasitic depsipeptides | ZOETIS SERVICES LLC (US) | 2023-10-03 | — | — | US | disclosed |
| US-11358960-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-06-14 | — | — | US | disclosed |
| US-20210205275-A1 | NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2021-07-08 | — | — | US | disclosed |
| EP-3799871-A2 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOTOTIC BAX | Dana Farber Cancer Institute, Inc. (US) | 2021-04-07 | — | — | EP | disclosed |
| EP-3792251-A1 | NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS | Elanco Tiergesundheit AG (CH) | 2021-03-17 | — | — | EP | disclosed |
| US-20210032234-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | DANA-FARBER CANCER INSTITUTE, INC. | 2021-02-04 | — | — | US | disclosed |
| EP-2766355-B1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | DANA FARBER CANCER INST INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| WO-2020002091-A1 | SUBSTITUTED THIAZOLYLPYRROLONES, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-01-02 | — | — | WO | disclosed |
| US-20070070159-A1 | Ink composition, ink set and recording method | FUJI PHOTO FILM CO., LTD. | 2007-03-29 | — | — | US | disclosed |
| US-20070070159-A1 | Ink composition, ink set and recording method | FUJI PHOTO FILM CO., LTD. | 2007-03-29 | — | — | US | disclosed |
| US-20070052783-A1 | Ink for inkjet printing ink set for inkjet printing inkjet recording material and producing method for inkjet recording material and inkjet recording method | FUJIFILM CORPORATION (JP) | 2007-03-08 | — | — | US | disclosed |
| US-20070052783-A1 | Ink for inkjet printing ink set for inkjet printing inkjet recording material and producing method for inkjet recording material and inkjet recording method | FUJIFILM CORPORATION (JP) | 2007-03-08 | — | — | US | disclosed |
| US-20070042997-A1 | Medicament for treatment of dermal pigmentation | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2007-02-22 | — | — | US | disclosed |
| US-20070042997-A1 | Medicament for treatment of dermal pigmentation | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2007-02-22 | — | — | US | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032234-A1 | PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX | BAX, BAD, CASP3 | ALDH1A1 3612/4885HPGD 968/4885NTRK1 3806/4885 |
| US-10844053-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | BAX, BAD, CASP3 | ALDH1A1 3612/4885HPGD 968/4885NTRK1 3806/4885 |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | ALDH1A1 355/4885HPGD 3159/4885NTRK1 777/4885 |
| US-11771738-B2 | Endoparasitic depsipeptides | VIP, PREP, VIPR1 | ALDH1A1 2109/4885HPGD 1639/4885NTRK1 4878/4885 |
| US-11358960-B2 | Pyrazol-3-ones that activate pro-apoptotic BAX | BAX, BAD, CASP3 | ALDH1A1 3612/4885HPGD 968/4885NTRK1 3806/4885 |
| US-20210205275-A1 | NEUROPROTECTIVE COMPOSITIONS AND METHODS OF USING THE SAME | GAP43, NLN, SMN1; SMN2 | ALDH1A1 1731/4885HPGD 1610/4885NTRK1 2964/4885 |
| US-20070042997-A1 | Medicament for treatment of dermal pigmentation | TYR, XDH, XPA | ALDH1A1 140/4885HPGD 57/4885NTRK1 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.