Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23716167 | 0.82 | FFAR2 (0.47) | FFAR2BRD4HDAC4HDAC7HDAC5 | |
| SCHEMBL15787299 | 0.82 | LMNA (0.44) | ROCK2POLBALDH1A1CNR1LMNA | |
| SCHEMBL15787345 | 0.82 | LMNA (0.44) | ROCK2POLBALDH1A1CNR1LMNA | |
| SCHEMBL6714743 | 0.82 | FOLH1 (0.55) | BRD4SLC6A3CYP2C9CYP2C19MEN1 | |
| SCHEMBL5427932 | 0.82 | FOLH1 (0.55) | BRD4SLC6A3CYP2C9CYP2C19MEN1 | |
| SCHEMBL31173416 | 0.82 | FOLH1 (0.55) | BRD4SLC6A3CYP2C9CYP2C19MEN1 | |
| SCHEMBL1712339 | 0.81 | CYP2D6 (0.50) | POLBCYP2C9CYP2C19MEN1CYP2D6 | |
| SCHEMBL1964866 | 0.81 | CYP2D6 (0.50) | POLBCYP2C9CYP2C19MEN1CYP2D6 | |
| SCHEMBL5225847 | 0.81 | CYP2D6 (0.50) | POLBCYP2C9CYP2C19MEN1CYP2D6 | |
| SCHEMBL6203749 | 0.81 | MDM2 (0.50) | FFAR2BRD4HDAC4HDAC7HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4702033-A1 | DESMURAMYLPEPTIDE DIACIDS AS NOD2 AGONISTS AND USE THEREOF | Imhotex Limited (GB) | 2026-03-04 | — | — | EP | disclosed |
| WO-2024224086-A1 | DESMURAMYLPEPTIDE DIACIDS AS NOD2 AGONISTS AND USE THEREOF | Imhotex Limited (GB) | 2024-10-31 | — | — | WO | disclosed |
| WO-2020140956-A1 | PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-07-09 | — | — | WO | disclosed |
| US-9233937-B2 | Method of stimulating insulin secretion and/or modulating INS-1 kinase with substituted pyrazinones and/or substituted tetrahydroquinoxalinones | MERCK PATENT GMBH (FR) | 2016-01-12 | — | — | US | disclosed |
| US-20140329837-A1 | ARYLPYRAZINONES SUCH AS BUT NOT LIMITED TO 3-(4-CHLOROPHENYL-1-ETHYLPYRAZIN-2-(1H0)-ONE | MERCK PATENT GMBH (FR) | 2014-11-06 | — | — | US | disclosed |
| US-8815859-B2 | Substituted pyrazin-2-ones and substituted 5,6,7,8-tetrahydroquinoxalin-2-ones and methods of use thereof | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20110046159-A1 | Arylpyrazinone derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes | MERCK PATENT GESELLSCHAFT (DE) | 2011-02-24 | — | — | US | disclosed |
| EP-0826667-B1 | 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles | BASF AG (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0492171-B1 | 4-Chloro-1-(ethoxymethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile, and its use as insecticide, nematocide and acaricide | AMERICAN CYANAMID CO (US) | 2000-08-02 | — | — | EP | disclosed |
| EP-0826667-A1 | 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles | AMERICAN CYANAMID COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |
| US-5625082-A | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-04-29 | — | — | US | disclosed |
| US-5380876-A | 2-aryl-5(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles | AMERICAN CYANAMID COMPANY (US) | 1995-01-10 | — | — | US | disclosed |
| US-5288901-A | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles | AMERICAN CYANAMID COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0492171-A1 | 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles | AMERICAN CYANAMID COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
| US-5118816-A | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles | AMERICAN CYANAMID COMPANY (US) | 1992-06-02 | — | — | US | disclosed |
| US-4115385-A | PENICILLINS | PFIZER INC. (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329837-A1 | ARYLPYRAZINONES SUCH AS BUT NOT LIMITED TO 3-(4-CHLOROPHENYL-1-ETHYLPYRAZIN-2-(1H0)-ONE | IAPP, GPR119, GLP1R | FFAR2 845/4885BRD4 1119/4885HDAC4 846/4885 |
| US-20110046159-A1 | Arylpyrazinone derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes | GLP1R, GPR119, IAPP | FFAR2 606/4885BRD4 1765/4885HDAC4 1686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.