Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196527 | 0.85 | FLT3 (0.41) | FLT3MAPT | |
| SCHEMBL8253524 | 0.69 | MAPT (0.45) | ALDH1A1MAPTKDM4EMEN1LMNA | |
| SCHEMBL7484806 | 0.69 | FLT3 (0.34) | PLA2G2AFLT3ALDH1A1NPC1RAB9A | |
| SCHEMBL7485079 | 0.68 | LCK (0.36) | PLA2G2AALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL7485063 | 0.68 | PLA2G2A (0.33) | PLA2G2A | |
| SCHEMBL22014435 | 0.67 | POLB (0.36) | BACE1ALDH1A1BCAT2NPC1RAB9A | |
| SCHEMBL8255374 | 0.66 | MAPT (0.49) | ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL8249959 | 0.66 | ALDH1A1 (0.44) | FLT3ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL16772616 | 0.65 | MEN1 (0.64) | BACE1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6846138 | 0.65 | BCAT2 (0.53) | BACE1MAPTBCAT2TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204644-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2000078725-A1 | SYNTHESIS OF SUBSTITUTED AMIDINES | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000078724-A2 | IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2000-12-28 | — | — | WO | disclosed |