Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687500 | 0.94 | MMP8 (0.49) | MMP8LMNAPIN1MEN1KMT2A | |
| SCHEMBL9686671 | 0.90 | MMP8 (0.46) | MMP8LMNAPIN1MEN1KMT2A | |
| SCHEMBL5835956 | 0.84 | KMT2A (0.51) | LMNAMEN1KMT2ACYP2C19TSHR | |
| SCHEMBL9796658 | 0.83 | MMP8 (0.48) | MMP8LMNAPIN1MEN1KMT2A | |
| SCHEMBL5836538 | 0.82 | LMNA (0.51) | LMNACYP2C19TDP1 | |
| SCHEMBL5908695 | 0.81 | MMP8 (0.51) | MMP8LMNAPIN1MEN1KMT2A | |
| SCHEMBL27419364 | 0.81 | MMP8 (0.46) | MMP8LMNAPIN1MEN1KMT2A | |
| SCHEMBL9685959 | 0.78 | SMN1; SMN2 (0.48) | MMP8LMNAPIN1MEN1KMT2A | |
| SCHEMBL5836723 | 0.78 | KMT2A (0.55) | LMNAMEN1KMT2ACYP2C19TSHR | |
| SCHEMBL28026121 | 0.78 | KMT2A (0.55) | LMNAMEN1KMT2ACYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061745-A1 | Tetrahydroisoquinoline compounds, processes for preparation thereof and pharmaceutical composition containing them | Tanabe Seiyaku Co., Ltd. (JP) | 1982-10-06 | — | — | EP | disclosed |