SCHEMBL7490899

SCHEMBL7490899

O=S(=O)(Cn1ncnc1-c1ccccc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.45
HDAC6 Q9UBN7 2/20 0.45
PSIP1 O75475 1/20 0.39
AURKA O14965 1/20 0.39
ALDH1A1 P00352 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
LMNA P02545 1/20 0.36
RAB9A P51151 1/20 0.36
MMP2 P08253 1/20 0.36
MMP7 P09237 1/20 0.36
MMP14 P50281 1/20 0.36
HSD11B1 P28845 1/20 0.35
P2RX7 Q99572 1/20 0.35
MEN1 O00255 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
MCOLN3 Q8TDD5 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.34
USP2 O75604 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7481950 0.82 ALDH1A1 (0.38) PSIP1ALDH1A1SMN1; SMN2NPC1LMNA
SCHEMBL7487578 0.81 HDAC1 (0.48) HDAC1HDAC6PSIP1NPC1RAB9A
SCHEMBL7482230 0.80 HDAC1 (0.47) HDAC1HDAC6ALDH1A1SMN1; SMN2LMNA
SCHEMBL7486763 0.77 NSD2 (0.39) HDAC1HDAC6HSD11B1P2RX7PTGS2
SCHEMBL7480824 0.77 TDP1 (0.35) PSIP1ALDH1A1SMN1; SMN2NPC1LMNA
SCHEMBL7482618 0.76 PSIP1 (0.41) PSIP1ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL5207841 0.73 HDAC1 (0.58) HDAC1HDAC6P2RX7PTGDR2PTGS2
SCHEMBL10304515 0.69 HDAC1 (0.48) HDAC1HDAC6ALDH1A1SMN1; SMN2P2RX7
SCHEMBL3859058 0.66 HDAC1 (0.45) HDAC1HDAC6ALDH1A1SMN1; SMN2NPC1
SCHEMBL28118890 0.64 ESR1 (0.48) ALDH1A1SMN1; SMN2NPC1LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214322-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-19 EP disclosed
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US disclosed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO disclosed