Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493128 | 0.86 | EPHX2 (0.40) | TACR1PPARAPPARGFDPSALDH1A1 | |
| SCHEMBL7484970 | 0.79 | MEN1 (0.47) | PPARAPPARGFDPSALDH1A1RAB9A | |
| SCHEMBL7493051 | 0.74 | ALDH1A1 (0.58) | HSD17B10ALDH1A1HTTHDAC3HDAC4 | |
| SCHEMBL7491428 | 0.72 | HDAC3 (0.40) | HSD17B10PPARAPPARGFDPSALDH1A1 | |
| SCHEMBL11551473 | 0.71 | PPARG (0.51) | HSD17B10PPARAPPARGTSHR | |
| SCHEMBL11077889 | 0.69 | CHRM1 (0.52) | PPARGFDPSALDH1A1BCL2L1TSHR | |
| SCHEMBL15650312 | 0.68 | ALDH1A1 (0.70) | ALDH1A1HTTRAB9AAOC3GAA | |
| SCHEMBL7874806 | 0.68 | PPARA (0.45) | HSD17B10PPARAPPARGALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL9499441 | 0.67 | FDPS (0.56) | FDPSALDH1A1TSHRHDAC3HDAC4 | |
| SCHEMBL14528082 | 0.67 | FDPS (0.62) | FDPSAOC3BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462042-B1 | TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITORS; INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, CANCER, CARDIO-VASCULAR DISEASES, RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, NEURODEGENERATION, ALZHEIMER'S DISEASE, STROKE | DARWIN DISCOVERY LIMITED (GB) | 2002-10-08 | — | — | US | disclosed |
| EP-1237867-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044188-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |