Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7386963 | 0.90 | ACSS2 (0.43) | ACSS2BRPF1PTGER4RORCCYP11B1 | |
| Bromide SCHEMBL7489164 | 0.85 | ENPP3 (0.39) | BRPF1RORC | |
| Bromide SCHEMBL7390736 | 0.78 | ALB (0.38) | ACSS2RORC | |
| Bromide SCHEMBL7388146 | 0.76 | TDP2 (0.36) | ACSS2 | |
| SCHEMBL7491020 | 0.76 | BRPF1 (0.42) | ACSS2BRPF1SMARCA2BRD1BRPF3 | |
| SCHEMBL10022436 | 0.73 | BRPF1 (0.44) | ACSS2BRPF1SMARCA2BRD1BRPF3 | |
| SCHEMBL10054048 | 0.71 | BRPF1 (0.50) | ACSS2BRPF1SMARCA2BRD1BRPF3 | |
| Bromide SCHEMBL7386874 | 0.71 | SNCA (0.44) | CYP11B1CYP11B2 | |
| Bromide SCHEMBL7388733 | 0.70 | SNCA (0.43) | — | |
| SCHEMBL21335575 | 0.70 | BRPF1 (0.44) | ACSS2BRPF1SMARCA2BRD1BRPF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918768-B1 | AROMATIC AMIDINE DERIVATIVES USEFUL AS SELECTIVE THROMBIN INHIBITORS | C & C RES LAB (KR) | 2002-01-09 | — | — | EP | disclosed |
| US-6201006-B1 | ANTICOAGULANTS | C & C RESEARCH LABORATORIES (KR) | 2001-03-13 | — | — | US | disclosed |