Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CBS | P35520 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495176 | 0.91 | PTGS2 (0.63) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL17341744 | 0.84 | PTGS2 (0.68) | PTGS2CYP3A4CBSLTA4HACHE | |
| Bisnorstriatol SCHEMBL9396838 | 0.81 | PTGS2 (0.77) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL10149325 | 0.78 | LTA4H (0.74) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL5644857 | 0.78 | DRD2 (0.59) | — | |
| SCHEMBL2991078 | 0.77 | PTGS2 (0.60) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL23777443 | 0.75 | PTGS2 (0.58) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL24299329 | 0.75 | PTGS2 (0.58) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL70008 | 0.75 | PTGS2 (0.86) | PTGS2CYP3A4CBSLTA4HACHE | |
| SCHEMBL4967337 | 0.75 | ESR1 (0.62) | PTGS2CYP3A4LTA4HACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638075-B1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5677322-A | THERAPY FOR AGING, DIABETES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| EP-0638075-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994019335-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |