Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495992 | 0.88 | TSHR (0.38) | TSHRALDH1A1PTAFRGALR3RAB9A | |
| SCHEMBL7846010 | 0.80 | ALDH1A1 (0.35) | ALDH1A1KMT2A | |
| SCHEMBL7835036 | 0.77 | CA12 (0.41) | ALDH1A1 | |
| SCHEMBL9445884 | 0.67 | NOTUM (0.44) | TSHRNOTUMKMT2A | |
| SCHEMBL7835032 | 0.67 | CNR1 (0.36) | — | |
| SCHEMBL11783850 | 0.66 | HSD17B10 (0.58) | TSHRALDH1A1NOTUMKMT2A | |
| SCHEMBL4851536 | 0.65 | ALDH1A1 (0.44) | TSHRALDH1A1NOTUM | |
| SCHEMBL9445882 | 0.64 | HTR7 (0.42) | TSHRALDH1A1NOTUMGALR3RAB9A | |
| SCHEMBL6913393 | 0.64 | ALDH1A1 (0.54) | ALDH1A1 | |
| SCHEMBL30675636 | 0.64 | NOTUM (0.48) | TSHRALDH1A1NOTUMRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734386-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LAB (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-0734386-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | Abbott Laboratories (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5486525-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995016687-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LABORATORIES (US) | 1995-06-22 | — | — | WO | disclosed |