Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494763 | 0.89 | TSPO (0.45) | TSPOTSHRSMN1; SMN2GAAMAPT | |
| SCHEMBL7501779 | 0.87 | TSPO (0.55) | TSPOTSHRSMN1; SMN2GAAMAPT | |
| SCHEMBL7493004 | 0.80 | TSPO (0.61) | TSPOSMN1; SMN2RXFP1TP53 | |
| SCHEMBL7499739 | 0.76 | MAOB (0.48) | TSPOTSHRGAAMAPTPOLB | |
| SCHEMBL7751594 | 0.75 | TSPO (0.50) | TSPOTSHRSMN1; SMN2GAAMAPT | |
| SCHEMBL6256479 | 0.74 | TSPO (0.71) | TSPOTSHRSMN1; SMN2GAAMAPT | |
| SCHEMBL4836958 | 0.72 | TSPO (0.61) | TSPOHPGD | |
| SCHEMBL7750505 | 0.72 | TSPO (0.61) | TSPOTSHRSMN1; SMN2GAAMAPT | |
| SCHEMBL7496512 | 0.72 | TSPO (0.47) | TSPOTSHRSMN1; SMN2MAPTPOLB | |
| SCHEMBL5747445 | 0.72 | TSPO (0.61) | TSPOSMN1; SMN2HPGDKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000063-B1 | 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY | SANOFI SYNTHELABO (FR) | 2002-10-23 | — | — | EP | disclosed |