Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.43 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488464 | 0.96 | ITGB3 (0.46) | ITGB3ITGAVITGA2BF2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL8459490 | 0.87 | ITGB3 (0.55) | ITGB3ITGAVITGA2BCA12CA1 | |
| SCHEMBL7494914 | 0.83 | LMNA (0.43) | ITGB3ITGAVITGA2BPKMALDH1A1 | |
| SCHEMBL7490918 | 0.82 | ITGB3 (0.60) | ITGB3ITGAVITGA2B | |
| Hydrochloric Acid SCHEMBL7488066 | 0.81 | ITGB3 (0.59) | ITGB3ITGAVITGA2B | |
| SCHEMBL7487574 | 0.81 | ITGB3 (0.48) | ITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL7052150 | 0.80 | ITGB3 (0.68) | ITGB3ITGAVITGA2B | |
| SCHEMBL7484657 | 0.80 | ITGB3 (0.48) | ITGB3ITGAVITGA2BPKMALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7495244 | 0.79 | ITGB3 (0.66) | ITGB3ITGAVITGA2B | |
| SCHEMBL7495717 | 0.79 | RAB9A (0.43) | ITGB3ITGAVITGA2BF2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760658-B1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-0760658-A4 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO INC (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0760658-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO. INC. (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032710-A1 | COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION | MERCK & CO., INC. (US) | 1995-12-07 | — | — | WO | disclosed |