Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750788 | 0.88 | OPRM1 (0.47) | TP53MAPTF2F10F7 | |
| SCHEMBL12520898 | 0.79 | TP53 (0.53) | TP53MAPTSLC2A1C5AR1ESRRG | |
| SCHEMBL3570656 | 0.78 | TP53 (0.42) | TP53MAPTF2F10F7 | |
| SCHEMBL3573203 | 0.77 | RAF1 (0.40) | TP53MAPTOPRM1OPRD1C5AR1 | |
| SCHEMBL747155 | 0.76 | TP53 (0.38) | TP53MAPTF2F10F7 | |
| SCHEMBL3581435 | 0.75 | TP53 (0.41) | TP53MAPTF2F10F7 | |
| Hydrochloric Acid SCHEMBL748268 | 0.75 | TP53 (0.38) | TP53MAPTF2F10F7 | |
| SCHEMBL12521008 | 0.74 | TP53 (0.48) | TP53MAPTSLC2A1ESRRGBCL2 | |
| SCHEMBL12521175 | 0.74 | LPAR1 (0.41) | TP53MAPTOPRM1OPRD1C5AR1 | |
| SCHEMBL12520957 | 0.74 | TP53 (0.43) | TP53MAPTF2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |