Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745501 | 0.98 | TMEM97 (0.39) | TMEM97OPRM1OPRD1SSTR4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL752637 | 0.97 | TMEM97 (0.38) | TMEM97OPRM1OPRD1SSTR4ALDH1A1 | |
| SCHEMBL748523 | 0.90 | LPAR1 (0.38) | OPRM1OPRD1PSEN1PSEN2APH1B | |
| SCHEMBL748611 | 0.89 | TP53 (0.38) | TMEM97OPRM1OPRD1ALDH1A1KMT2A | |
| SCHEMBL747114 | 0.89 | C5AR1 (0.41) | TMEM97OPRM1OPRD1SSTR4PSEN1 | |
| SCHEMBL745512 | 0.88 | OPRM1 (0.34) | TMEM97OPRM1OPRD1ALDH1A1PSEN1 | |
| SCHEMBL748563 | 0.88 | MBTPS1 (0.39) | OPRM1OPRD1PSEN1PSEN2APH1B | |
| Hydrochloric Acid SCHEMBL747110 | 0.87 | OPRM1 (0.34) | TMEM97OPRM1OPRD1ALDH1A1PSEN1 | |
| SCHEMBL746654 | 0.87 | OPRM1 (0.34) | TMEM97OPRM1OPRD1ALDH1A1KMT2A | |
| SCHEMBL745473 | 0.87 | KMT2A (0.44) | TMEM97OPRM1OPRD1KMT2ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |