SCHEMBL7496148

SCHEMBL7496148

CCCN(CCC)C(=O)CNc1ccnc(-c2ccccc2)n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 11/20 0.51
CYP3A4 P08684 10/20 0.51
CYP2D6 P10635 8/20 0.51
ALDH1A1 P00352 5/20 0.51
USP2 O75604 4/20 0.51
MAPK1 P28482 4/20 0.51
CYP2C19 P33261 8/20 0.46
HPGD P15428 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
TP53 P04637 2/20 0.46
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
HSD17B10 Q99714 1/20 0.46
CLK4 Q9HAZ1 4/20 0.44
TSHR P16473 4/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 2/20 0.44
ALOX15 P16050 1/20 0.44
PRKCA P17252 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7501309 0.83 ADORA1 (0.57) ALDH1A1HPGDKDM4EMAPTMEN1
SCHEMBL7505001 0.82 MEN1 (0.53) CYP1A2CLK4MEN1KMT2A
SCHEMBL7502465 0.79 PTGS2 (0.49)
SCHEMBL7212190 0.78 SMN1; SMN2 (0.46) CYP1A2ALDH1A1MAPK1CYP2C19HPGD
SCHEMBL7507585 0.78 ALDH1A1 (0.45) CYP1A2ALDH1A1MAPK1CYP2C19SMN1; SMN2
SCHEMBL7502926 0.77 SMN1; SMN2 (0.40) CYP1A2ALDH1A1MAPK1CYP2C19HPGD
SCHEMBL7499394 0.75 PDE4B (0.50) ALDH1A1HPGDSMN1; SMN2TP53KDM4E
SCHEMBL7495639 0.74 ALDH1A1 (0.58) CYP1A2CYP3A4ALDH1A1MAPK1CYP2C19
SCHEMBL7503138 0.74 TSPO (0.42) CYP1A2ALDH1A1MAPK1CYP2C19SMN1; SMN2
SCHEMBL7498883 0.73 SMN1; SMN2 (0.42) CYP1A2CYP3A4ALDH1A1CYP2C19HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0826673-B1 ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO (JP) 2002-11-20 EP disclosed
US-5972946-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0826673-A1 ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1998-03-04 EP disclosed