Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27683794 | 0.84 | KCNMA1 (0.64) | KCNMA1MAPTRAB9ANPC1ALDH1A1 | |
| SCHEMBL6454614 | 0.77 | ALDH1A1 (0.81) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL7253758 | 0.76 | KCNMA1 (0.57) | KCNMA1ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL7253753 | 0.76 | KCNMA1 (0.57) | KCNMA1ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL18275000 | 0.76 | POLB (0.58) | KCNMA1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7157788 | 0.76 | CRHBP (0.67) | KCNMA1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1138444 | 0.75 | KCNMA1 (0.56) | KCNMA1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL249599 | 0.75 | KCNMA1 (0.56) | KCNMA1MAPTSMN1; SMN2HTTMEN1 | |
| SCHEMBL6819265 | 0.74 | CXCR2 (0.61) | KCNMA1MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5226740 | 0.74 | KCNMA1 (0.67) | KCNMA1MAPTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679641-B1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | EISAI CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5854274-A | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives | EISAI CO., LTD. (JP) | 1998-12-29 | — | — | US | disclosed |
| US-5846969-A | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives | EISAI CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| US-5834462-A | ANTITUMOR AGENTS; ANTICARCINOGENIC AGENTS PARTICULARLY FOR NASOPHARYNGEL, PULMONARY, INTESTINAL, MAMMARY, UTERUS, GASTRIC, OVARIAN OR LIVER CANCER AND ALSO LEUKEMIA | EISAI CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0679641-A1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | Eisai Co., Ltd. (JP) | 1995-11-02 | — | — | EP | disclosed |