Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | PTGIR | P43119 | 7/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684703 | 0.80 | PTGIR (0.43) | PTGIRGSK3BHTT | |
| SCHEMBL11317135 | 0.80 | PTGIR (0.48) | PTGIRGSK3B | |
| SCHEMBL1150853 | 0.77 | CYP4F2 (0.41) | KDM5AKDM5BPTGIRKDM4EALDH1A1 | |
| SCHEMBL8135631 | 0.75 | GSK3B (0.51) | CDK2GSK3BKDM4EGAA | |
| SCHEMBL5548056 | 0.73 | GAA (0.48) | KDM5AKDM5BMAOAMAOBSCD | |
| SCHEMBL823438 | 0.73 | ALDH1A1 (0.46) | PTGIRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL21384222 | 0.72 | MAPK1 (0.49) | KDM5AKDM5BMAOAMAOBSCD | |
| SCHEMBL28898122 | 0.72 | LOXL2 (0.53) | KDM5AKDM5BMAOAMAOBMETAP2 | |
| SCHEMBL4768685 | 0.71 | MAPK10 (0.42) | KDM4EALDH1A1GAAALOX15TSHR | |
| SCHEMBL5547391 | 0.71 | LMNA (0.41) | KDM5AKDM5BKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140906-A4 | IMIDAZOLONES AND THEIR USE IN TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER DISORDERS | SYNAPTIC PHARMA CORP (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-1140906-A1 | IMIDAZOLONES AND THEIR USE IN TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035907-A1 | IMIDAZOLONES AND THEIR USE IN TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
| US-6046331-A | Imidazolones and their use in treating benign prostatic hyperplasia and other disorders | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |