SCHEMBL7498154

SCHEMBL7498154

CON=C(C(C)=NOCc1ccccc1C(=NOC)C(=O)OC)c1ccc(Oc2cccc(C(F)(F)F)c2)cc1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.57
MAPK14 Q16539 1/20 0.41
RXFP1 Q9HBX9 2/20 0.38
MAOB P27338 1/20 0.37
GCGR P47871 1/20 0.37
CHEK2 O96017 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7494032 0.92 HIF1A (0.47) HIF1AMAPK14RXFP1MAOBGCGR
SCHEMBL8544633 0.88 HIF1A (0.44) HIF1AMAPK14RXFP1MAOBGCGR
SCHEMBL8721314 0.88 HIF1A (0.54) HIF1ARXFP1GAA
SCHEMBL7468302 0.85 HIF1A (0.60) HIF1AMAOBMAPT
SCHEMBL7467255 0.84 HIF1A (0.41) HIF1AMAPK14RXFP1GCGR
SCHEMBL7467258 0.84 HIF1A (0.41) HIF1AMAPK14RXFP1GCGR
SCHEMBL7500251 0.82 HIF1A (0.57) HIF1AMAOBMAPT
SCHEMBL12635931 0.82 HIF1A (0.64) HIF1ARXFP1GAA
SCHEMBL2321633 0.82 HIF1A (0.64) HIF1ARXFP1GAA
SCHEMBL9880011 0.82 HIF1A (0.64) HIF1ARXFP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6420423-B1 PESTICIDE FOR USE ON CEREALS, BEETS, FRUITS, BERRIES, AND BEANS; KILLS MITES, INSECTS, TERMITES, LICE, FLEAS, AND FUNGUS; TOLERATED WELL BE ANIMALS, PLANTS, AND FISH BAYER AKTIENGESELLSCHAFT (DE) 2002-07-16 US disclosed
EP-1207152-A2 Pesticides Bayer Aktiengesellschaft (DE) 2002-05-22 EP disclosed
US-5985921-A OXIDATION AND HYDROGENATION OF COMPOUNDS TO FORM INSECTICIDES AS AGROCHEMICALS NOVARTIS CORPORATION (US) 1999-11-16 US disclosed
EP-0865424-A1 PESTICIDES Novartis AG (CH) 1998-09-23 EP disclosed
WO-1997020809-A1 PESTICIDES NOVARTIS AG (CH) 1997-06-12 WO disclosed