Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 4/20 | 0.36 |
| ▸ | PHOSPHO1 | Q8TCT1 | 4/20 | 0.36 |
| ▸ | PMM2 | O15305 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5270640 | 0.78 | HSD17B10 (0.48) | HSD17B10ALDH1A1KDM4ETDP1MPI | |
| SCHEMBL645578 | 0.78 | TP53 (0.39) | HSD17B10ALDH1A1TDP1MPIPHOSPHO1 | |
| SCHEMBL7772481 | 0.77 | TUBB4A (0.42) | HSD17B10ALDH1A1KDM4ETDP1TSHR | |
| SCHEMBL2750548 | 0.72 | HSD17B10 (0.43) | HSD17B10ALDH1A1KDM4ETDP1MPI | |
| SCHEMBL23292676 | 0.71 | MAPT (0.52) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL11569176 | 0.71 | IDO1 (0.44) | HSD17B10ALDH1A1TDP1TSHRMEN1 | |
| SCHEMBL16141626 | 0.69 | HSD17B10 (0.41) | HSD17B10ALDH1A1APOBEC3GAPOBEC3ATDP1 | |
| SCHEMBL18850042 | 0.69 | MGLL (0.43) | HSD17B10ALDH1A1APOBEC3GKDM4ETDP1 | |
| Iodide SCHEMBL17509707 | 0.68 | HSD17B10 (0.40) | HSD17B10ALDH1A1APOBEC3GAPOBEC3ATDP1 | |
| SCHEMBL3310092 | 0.68 | ALDH1A1 (0.52) | HSD17B10ALDH1A1APOBEC3GKDM4EMPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265870-A1 | NEW CCR5 MODULATORS: BENZIMIDAZOLES OR BENZOTRIAZOLES | AstraZeneca AB (SE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001066525-A1 | NEW CCR5 MODULATORS: BENZIMIDAZOLES OR BENZOTRIAZOLES | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | disclosed |