Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9409888 | 0.82 | PTPN1 (0.54) | PTPN1CNR1 | |
| SCHEMBL23314180 | 0.81 | PARG (0.55) | BDKRB1 | |
| SCHEMBL2152785 | 0.80 | CDC25B (0.50) | — | |
| SCHEMBL7498185 | 0.79 | PTGS2 (0.62) | PTGS2PTGS1ESR1AKR1C3AKR1C2 | |
| SCHEMBL7499348 | 0.79 | PTGS2 (0.58) | PTGS2PTGS1ESR1AKR1C3AKR1C2 | |
| SCHEMBL17288555 | 0.79 | CASP6 (0.41) | PTGS2PTPN1AKR1C3AKR1C2 | |
| SCHEMBL9654263 | 0.77 | CDC25B (0.56) | PTPN1CNR1 | |
| SCHEMBL7497620 | 0.76 | PTGS1 (0.55) | PTGS2PTGS1ESR1 | |
| SCHEMBL7499994 | 0.75 | PTGS2 (0.54) | PTGS2PTGS1ESR1AKR1C3AKR1C2 | |
| SCHEMBL4030635 | 0.75 | PTGS2 (0.62) | PTGS2PTGS1AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966437-B1 | 5-AROYLNAPHTHALENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2002-06-12 | — | — | EP | disclosed |
| US-6150397-A | 5-(PYRIDYL, FURYL, OR THIENYL SUBSTITUTED)-6-SUBSTITUTED-2--2-NAPHTHALENESULFONAMIDES OF GIVEN FORMULA; INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE; TREATING INFLAMMATORY DISEASE SUCH AS GOUT, ARTHRITIS, MYOSITIS, SYNOVITIS | SYNTEX (U.S.A.) INC. (US) | 2000-11-21 | — | — | US | disclosed |
| EP-0966437-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| US-5962531-A | PROSTAGLANDIN SYNTHASE INHIBITOR; RHEUMATIC DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1998032732-A1 | 5-AROYLNAPHTHALENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |