Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 6/20 | 0.63 |
| ▸ | AHR | P35869 | 3/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495130 | 0.86 | PCSK9 (0.60) | PCSK9AHRLOXL2BRD4 | |
| SCHEMBL29403791 | 0.81 | LOXL2 (0.69) | PCSK9AHRLOXL2HRH4MTNR1A | |
| SCHEMBL401081 | 0.81 | LOXL2 (0.69) | PCSK9AHRLOXL2HRH4MTNR1A | |
| SCHEMBL28338445 | 0.81 | LOXL2 (0.69) | PCSK9AHRLOXL2HRH4MTNR1A | |
| SCHEMBL7490425 | 0.79 | PCSK9 (0.63) | PCSK9AHRLOXL2HRH4 | |
| SCHEMBL31672301 | 0.79 | AHR (0.62) | PCSK9AHRLOXL2MTNR1AMTNR1B | |
| SCHEMBL7491887 | 0.79 | PCSK9 (0.63) | PCSK9AHRLOXL2 | |
| SCHEMBL17454530 | 0.79 | AHR (0.67) | PCSK9AHRLOXL2 | |
| SCHEMBL28335219 | 0.79 | LOXL2 (0.67) | PCSK9AHRLOXL2MTNR1AMTNR1B | |
| SCHEMBL31065667 | 0.79 | BRD4 (0.60) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |